When it comes to maintaining optimal health, there are a few key players that often come to mind: exercise, a balanced diet, and plenty of sleep. But there are also lesser-known supplements that can have a significant impact on our overall well-being. Two of these supplements, TUDCA and NAC, have been gaining popularity in recent years for their powerful health benefits. In this article, we’ll explore the benefits of TUDCA and NAC and why they make the ultimate power couple for maintaining cognitive function and liver detox.
What is TUDCA?
Commonly known as TUDCA, Tauroursodeoxycholic acid is a bile acid that naturally exists in the human body. Normal bile acids are metabolized by bacteria into UDCA upon reaching the intestines, and ultimately bind to a taurine molecule to form TUDCA.
TUDCA, a bile acid that is water-soluble, differs from common bile acids, which have both water and fat-soluble ends, giving them a deterrent effect. This is beneficial for their biological function, which is emulsifying fats in the intestines to enhance absorption. However, when bile acids accumulate in the liver - a condition known as cholestasis which happens when the liver is unhealthy - they can harm cells by breaking down the membranes and triggering cell death. TUDCA and other water-soluble bile salts such as UDCA can contest this toxicity, thereby indirectly safeguarding cells from demise.
TUDCA is only recognized by earnest and committed bodybuilders. They utilize it to maintain their liver health and rejuvenation even when consuming oral steroids. TUDCA, which is deemed to be an effective organ detoxifier during cycles and for PCT, has become a common component in numerous bodybuilding supplements.
TUDCA has been utilized since ancient Asian medicinal practices due to its numerous health advantages, including the recuperation of ailing organs. In reality, due to the prominence of TUDCA, our forefathers needed to ascertain ways of acquiring it in bulk to expedite the healing process for the ill. They discovered that bear bile was an abundant source of it.
Luckily, we have discovered more ethical ways of producing enough TUDCA for the market, eliminating the need for the ruthless killing of bears. Consequently, TUDCA has become a globally recognized treatment for several health conditions such as gallstones and liver or biliary cirrhosis. What's more, recent studies have revealed that TUDCA offers a plethora of benefits for eyes, heart, and overall organ health. Additionally, it has been observed that TUDCA can also contribute positively to treating Parkinson's disease.
Why do we love to Combine TUDCA with NAC?
TUDCA + NAC by GREENDORSE is a supplement dedicated to liver health, combining two highly potent components: TUDCA and NAC. It contains 500 mg of TUDCA (tauroursodeoxycholic acid) possessing a chromatographic purity exceeding 98%, and 600 mg of NAC (N-acetyl-cysteine) which also has a chromatographic purity beyond 98%. The TUDCA + NAC capsules aid in promoting liver health and the body's natural detoxification paths.
TUDCA is chiefly recognized for its plethora of health advantages, specifically aiding digestion and bowel movement, safeguarding the liver from toxins and alcohol, and controlling cholesterol levels.
N-acetyl cysteine (NAC) is a derivative of cysteine available in supplement form. Maintaining an adequate intake of both cysteine and NAC has diverse health implications, such as restoring the body's most potent antioxidant, glutathione. Furthermore, N-acetyl cysteine facilitates the production of glutathione, a key antioxidant that neutralizes free radicals and is proven to provide liver protection. It has been found to be effective in treating acetaminophen overdose, as well as other liver conditions such as non-alcoholic fatty liver disease and liver damage caused by alcohol consumption.
Studies have also shown that NAC can help protect the liver from damage caused by toxins and pollutants, making it a valuable supplement for individuals who are exposed to environmental toxins on a regular basis. When taken together, TUDCA and NAC have been found to have synergistic effects, meaning that they work together to produce even greater benefits than they would on their own. This is due to their ability to increase levels of glutathione in the body, which is essential for both liver detox and cognitive function.
What are the key features of this liver support supplement?
Highly effective potency in treating cholestasis
Helps reduce liver enzymes
Fantastic antioxidant properties
Promotes glutathione levels
How to Take?
As a food supplement, for optimal results, adults should take two capsules once daily, preferably in the morning, 30-45 minutes before their breakfast meal, or as directed by the healthcare professional. Do not exceed the daily dose.
Steroid Use
For steroid users, integrating TUDCA into any routine cycle is crucial to protect your body from severe side-effects. Over a period, individuals who have been ingesting a reasonable amount of oral steroids can seriously burden their liver. Steroids lead to cell damage as they metabolize and pass through the liver. Steroid induced liver cell damage can result in jaundice and severe liver diseases. Additionally, steroids can directly thwart the production and liver's bile flow, known as cholestasis. TUDCA serves to facilitate bile flow (rectify cholestasis) and cleanse the liver.
TUDCA isn't solely beneficial during steroid cycles, but also in post cycle therapy (PCT). The strain on your heart and liver is a given when undertaking a steroid cycle. By persisting with body detoxification throughout post-cycle therapy, post-steroid usage, you can assist your body in expelling accumulated toxins. This can help you feel healthier and revert to your pre-cycle health status. Those who practice blasting and cruising (BnC) can also gain from using TUDCA, given its efficiency in liver detoxification even during BnC phases. To put it simply, this enables more blasting with decreased cruising.
Side Effects
Side effects associated with TUDCA are seldom mentioned as TUDCA is naturally occurring in the body. Nonetheless, its usage is not endorsed for pregnant women or kids.
The edge of choosing TUDCA in comparison to other support supplements like milk thistle is that while milk thistle solely benefits your liver, TUDCA significantly enhances your overall bile mobilization. Due to this, TUDCA surpasses any other cycle support supplement.
Diabetes and Weight loss
Research indicates that TUDCA aids in managing blood glucose and insulin levels, which clarifies its increasing popularity among individuals with diabetes. In addition, another research demonstrated that it assists in reducing fat and regulating weight in both males and females. In other words, it can facilitate weight reduction if you are obese, and if you're underweight, it can support in acquiring some lean mass.
TUDCA is also known for its potential benefits in promoting eye health. Research has shown that TUDCA may help protect against certain eye conditions, such as diabetic retinopathy and age-related macular degeneration. Additionally, TUDCA has been studied for its potential role in supporting heart health. It has been shown to have anti-inflammatory and antioxidant properties that may help reduce the risk of cardiovascular diseases. Furthermore, TUDCA has shown promise in the treatment of Parkinson's disease, with studies suggesting that it may help protect against the degeneration of dopamine-producing cells in the brain. Overall, TUDCA is a versatile compound with a wide range of potential health benefits. How is TUDCA from GREENDORSE is better than others? When bile acids back up in the liver, a clinical state called cholestasis occurs and when the liver is unhealthy, the regular bile salts can be damaging to cells by destroying the membranes and signaling for cell death. TUDCA and other water soluble bile salts like UDCA compete with this toxicity and thus indirectly protect cells from death. A healthy person produces very small amounts of TUDCA, and poor diet, decreased liver function, steroids, unsafe supplementation and certain medications can impair this process completely. Majority of TUDCA is chemically synthesized in China, US and Europe whose efficacy and safety is questionable compared to ones produced via bacterial expression and enzymatic conversion.
Our TUDCA is produced via a patented manufacturing process giving us an edge over our competitors owing to our process’s superiority in terms of yield and quality.
Besides, We are getting our TUDCA manufactured in compliance with the World Health Organization (WHO) Current Good Manufacturing Practices (cGMP) under strict conditions in state-of-the-art facilities. We provide 98-99% purity (levels by HPLC) for our TUDCA which is hardly claimed by any other brand.
References:
Sutherland, L. (2022). "Tauroursodeoxycholic Acid (TUDCA): A Promising Neuroprotective Agent." Restorative Medicine Digest. T
Patel, K. (2024). "TUDCA Benefits, Dosage, and Side Effects." Examine.com. This source provides a detailed overview of TUDCA, including its liver-protective effects, ability to improve insulin sensitivity, and potential uses in metabolic health.
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