Combat mental and physical stress, occasional anxiety, muscle cramps, poor sleep with Calm & Relax: Shoden Ashwagandha, Magnesium Glycinate, and Probiotic Strains
- riturathi803
- Jun 10, 2024
- 10 min read
Updated: Jul 28, 2024
Finding it challenging to manage the constant pressures of modern life? Introducing the Calm & Relax formula from GREENDORSE - a comprehensive solution designed to help you achieve a state of whole-body tranquility and rejuvenation. At the heart of this innovative supplement is a chelated form of magnesium, providing a highly bioavailable and potent 22% elemental magnesium. Magnesium is an essential mineral that plays a crucial role in over 300 enzymatic reactions within the body, yet many individuals struggle to obtain adequate amounts through diet alone. When magnesium levels are insufficient, it can lead to a host of unpleasant symptoms, including fatigue, irritability, nausea, and even muscle cramps or weakness. By supplying your body with this vital nutrient in its optimized glycinate form, the Calm & Relax formula helps support cardiovascular health, blood sugar regulation, DNA repair, energy metabolism, protein synthesis, and healthy nerve transmission - restoring balance and promoting a profound sense of whole-body calm.
But the benefits don't stop there. This meticulously crafted supplement also features the world's most potent and clinically studied form of ashwagandha, known as Shoden. This ancient adaptogenic herb has been revered for centuries for its remarkable ability to help the body adapt to and manage stress. Shoden ashwagandha, with its standardized 35% withanolide content and 11 international research publications, has been shown to effectively balance the stress hormone cortisol, making it a powerful ally in the fight against the detrimental effects of chronic anxiety and tension. By working in synergy with the magnesium, this Ayurvedic botanical can help soothe the mind, promote healthy sleep patterns, and support overall mental well-being.
To further enhance the calming and restorative properties of this formula, GREENDORSE has also included two clinically studied probiotic strains: Bifidobacterium longum and Lactobacillus helveticus. These beneficial bacteria have been specifically chosen for their ability to support stress management and healthy sleep cycles, providing a truly comprehensive approach to whole-body relaxation and rejuvenation.
Understanding the Trio: Shoden Ashwagandha, Magnesium Glycinate, and Probiotics
Ashwagandha:
Ashwagandha, a revered adaptogenic herb in traditional Ayurvedic medicine, has gained recognition worldwide for its stress-relieving properties. Shoden Ashwagandha that GREENDORSE uses in this formula is a patented form of Ashwagandha that boasts high bioavailability and effectiveness. This is the world’s most potent and clinically studied form of Ashwagandha, standardized to 35% withanolides. It helps regulate cortisol levels, the hormone associated with stress, thereby promoting a sense of calm and aiding in better sleep quality. Its ability to regulate cortisol, balance neurotransmitters, and support various bodily functions underscores its versatility and effectiveness in promoting mental and physical health. It also acts as a GABA mimetic, aiding in anxiety reduction and promoting mental well-being.
Here's how Ashwagandha helps manage stress and its overall benefits:
Managing Stress
Regulation of Cortisol Levels: Cortisol is a hormone released in response to stress. Ashwagandha has been shown to reduce cortisol levels, thereby reducing stress and its physiological effects.
Balancing Neurotransmitters: Ashwagandha may influence neurotransmitter balance in the brain, particularly GABA (gamma-aminobutyric acid) and serotonin, which are involved in mood regulation and relaxation.
Enhancing Sleep Quality: Improved sleep quality is a significant factor in stress management. Ashwagandha has been noted to improve sleep patterns, which can help reduce stress and improve overall mental health.
Overall Benefits
Anxiety and Depression Relief: Ashwagandha has anxiolytic (anxiety-reducing) properties. Studies have shown that it can reduce symptoms of anxiety and depression in some individuals.
Cognitive Function: Ashwagandha may support cognitive function, including memory, attention, and information processing speed. This is particularly beneficial in conditions of stress and fatigue.
Energy and Stamina: By reducing stress and improving sleep, Ashwagandha can help boost energy levels and physical stamina.
Immune System Support: Ashwagandha has immunomodulatory effects, meaning it can help support and regulate the immune system, enhancing the body's resilience against infections and illnesses.
Anti-inflammatory and Antioxidant Effects: Ashwagandha possesses anti-inflammatory and antioxidant properties, which can help reduce inflammation and protect cells from damage caused by free radicals.
Thyroid Function: Ashwagandha has been found to support thyroid function, particularly in cases of hypothyroidism (underactive thyroid).
Blood Sugar Regulation: Some studies suggest that Ashwagandha can help regulate blood sugar levels, which can be beneficial for individuals with diabetes or those at risk of developing diabetes.
Muscle Strength and Recovery: Ashwagandha is often used by athletes to enhance muscle strength, improve muscle recovery, and reduce exercise-induced muscle damage.
Mechanisms of Action
Adaptogenic Properties: Ashwagandha helps the body resist various stressors, whether physical, chemical, or biological.
Hormonal Regulation: It helps in balancing hormones and stabilizing physiological processes.
Neuroprotective Effects: Ashwagandha supports nerve growth and health, protecting the brain from damage and degeneration.
Modulation of HPA Axis: The herb helps modulate the hypothalamic-pituitary-adrenal (HPA) axis, which plays a critical role in stress response.
"Ashwagandha Study on Cortisol Reduction: 60-day trial with 64 participants showed a 27.9% reduction in cortisol." Study Link
“Study on Anxiety and Stress Levels: 6-week trial of Ashwagandha with 75 participants showed a significant decrease in anxiety levels." Study Link
Consuming ashwagandha for 60 days also showed a significant increase in sleep quality (+30%) and Relaxation (+40%).
Magnesium:
Muscle cramps can be a painful and frustrating experience, often caused by deficiencies in magnesium. Magnesium is an essential mineral involved in over 300 enzymatic reactions in the body, impacting vital functions such as cardiovascular health, blood sugar regulation, DNA repair, energy metabolism, protein synthesis, and nerve transmission (NIH, 2024). Despite its critical role, many individuals are deficient in magnesium, which can manifest as fatigue, irritability, muscle cramps, and weakness. GREENDORSE’s calm & formulation uses chelated form of Magnesium glycinate offering 22% elemental magnesium, providing optimal bioavailability and minimal gastrointestinal disturbance compared to other forms.
Research has shown that magnesium supplementation can have significant benefits in stress management, athletic performance, and muscle relaxation. Here are key findings from scientific studies:
Stress Management
1. Cortisol Regulation:
- Magnesium plays a role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which controls the release of stress hormones like cortisol. Research published in the journal Neuropharmacology (2018) suggests that magnesium supplementation can help modulate the stress response and reduce cortisol levels, thereby promoting a more balanced stress response.
2. Anxiety and Mood Improvement:
- Studies have indicated that magnesium deficiency may contribute to anxiety and mood disorders. Supplementing with magnesium has been shown to have anxiolytic effects, helping to reduce symptoms of anxiety and improve mood. Research in the Journal of Research in Medical Sciences (2012) found that magnesium supplementation was effective in reducing symptoms of depression and anxiety in elderly patients.
Athletic Performance
1. Muscle Function and Endurance:
- Magnesium is crucial for muscle function, including relaxation and contraction. Adequate magnesium levels support energy production (ATP synthesis) and electrolyte balance, which are essential for muscle performance during exercise. Research in the Journal of Nutrition (2002) suggests that magnesium supplementation may improve physical performance in athletes by enhancing muscle oxygenation and energy metabolism.
2. Electrolyte Balance:
- During exercise, magnesium helps maintain electrolyte balance and supports proper hydration. This is important for preventing muscle cramps and maintaining overall muscle function and performance.
Muscle Relaxation and Recovery
1. Anti-Inflammatory Effects:
- Magnesium has anti-inflammatory properties that may help reduce muscle soreness and inflammation after intense physical activity. Studies, such as those published in the Journal of Sports Science and Medicine (2013), have demonstrated that magnesium supplementation can alleviate muscle cramps and enhance recovery time post-exercise.
2. Regulation of Muscle Contraction:
- Magnesium regulates calcium levels within muscle cells, which is essential for proper muscle contraction and relaxation. Maintaining adequate magnesium levels helps prevent muscle spasms and promotes overall muscle relaxation.
Mechanisms of Action
The mechanisms through which magnesium supports stress management, athletic performance, and muscle relaxation are multifaceted:
- Regulation of Stress Hormones: Magnesium helps regulate the release of stress hormones like cortisol, promoting a more balanced stress response.
- Energy Production: Magnesium is involved in ATP synthesis, which provides energy for muscle contraction during physical activity.
- Muscle Relaxation: Magnesium facilitates calcium ion transport across cell membranes, influencing muscle contraction and relaxation.
- Anti-Inflammatory Effects: Magnesium acts as a natural anti-inflammatory agent, reducing inflammation and oxidative stress that contribute to muscle soreness and fatigue.
Magnesium supplementation offers a range of benefits for stress management, athletic performance, and muscle relaxation. Whether you're looking to enhance your physical performance, manage stress more effectively, or support muscle recovery after exercise, ensuring adequate magnesium intake through diet or supplementation can play a crucial role in maintaining overall health and well-being.
Probiotics (Bifidobacterium longum and Lactobacillus helveticus):
Research on Bifidobacterium longum and Lactobacillus helveticus, particularly in relation to stress, sleep, depression, and anxiety, highlights their potential as beneficial probiotic strains for mental health and overall well-being. Here are some key findings based on scientific studies:
Bifidobacterium longum
1. Stress Reduction:
- A study published in Neurogastroenterology & Motility (2016) found that supplementation with Bifidobacterium longum 1714 reduced physiological responses to stress in healthy individuals. Participants showed lower levels of cortisol (a stress hormone) and reduced subjective feelings of stress compared to the placebo group.
2. Anxiety and Mood Regulation:
- Research in Psychopharmacology (2015) demonstrated that Bifidobacterium longum 1714 reduced anxiety-like behavior and normalized anxiety-related physiological responses in mice. This suggests potential anxiolytic (anti-anxiety) effects in humans as well.
3. Depression and Mood Disorders:
- While more research is needed on direct effects in humans, some animal studies, such as those published in BMC Psychiatry (2011), have suggested that Bifidobacterium longum may have antidepressant-like effects, possibly through its influence on gut-brain communication pathways and neurotransmitter systems.
Lactobacillus helveticus
1. Stress Reduction:
- Lactobacillus helveticus has been extensively studied for its stress-reducing properties. Research published in Journal of Physiological Anthropology (2017) demonstrated that supplementation with Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduced psychological distress and improved mood in individuals with chronic stress.
2. Sleep Quality:
- A study in European Journal of Nutrition (2019) investigated the effects of Lactobacillus helveticus on sleep quality and found that supplementation improved sleep parameters, such as sleep efficiency and time spent awake after sleep onset, suggesting potential benefits for sleep disorders.
3. Anxiety and Depression:
- Clinical trials have shown promising results regarding Lactobacillus helveticus's effects on anxiety and depression. For example, a study in Psychiatry Research (2018) reported that supplementation with Lactobacillus helveticus NS8 significantly reduced symptoms of depression and anxiety in adults with major depressive disorder.
Mechanisms of Action
The mechanisms through which Bifidobacterium longum and Lactobacillus helveticus exert their beneficial effects on stress, sleep, depression, and anxiety are still being elucidated. However, several hypotheses include:
- Gut-Brain Axis: Probiotics can influence communication between the gut and the brain through the vagus nerve and production of neurotransmitters such as serotonin and gamma-aminobutyric acid (GABA), which are involved in mood regulation.
- Immune Modulation: Probiotics can modulate immune responses, which may indirectly affect mental health by reducing inflammation and oxidative stress.
- Microbiota Composition: Improving the balance of gut microbiota may promote overall health, including mental well-being, by supporting digestion, nutrient absorption, and immune function.
The research on Bifidobacterium longum and Lactobacillus helveticus underscores their potential as natural supplements to support mental health and well-being. While more studies are needed to fully understand their mechanisms and efficacy in different populations, current evidence suggests that these probiotics may offer valuable adjunctive support for managing stress, improving sleep quality, and alleviating symptoms of depression and anxiety.
Research indicates that Lactobacillus helveticus, often in combination with Bifidobacterium longum, shows promising effects in reducing symptoms of stress, anxiety, and depression in humans.
In several studies, supplementation with these probiotics has led to significant reductions in psychological distress. For example, A human study of 55 participants with mild depression or anxiety, ages 30 to 60, was conducted to determine the effects of these probiotic combination on anxiety, depression, stress, and coping strategies. A human study of 55 participants with mild depression or anxiety, ages 30 to 60, was conducted to determine the effects of these probiotic combination on anxiety, depression, stress, and coping strategies.
The probiotic-supplemented subjects had a significantly larger drop in measures of anxiety and depression than did placebo recipients as follows:
49% drop in the global severity index, a measure of overall psychological distress
50% decrease in depression scores
60% decrease in anger-hostility scores
36% decrease in the hospital anxiety and depression score (HADS)
13% decrease in urinary free cortisol, a hormonal measure of chronic stress, which was not seen in placebo patients
Study link: https://pubmed.ncbi.nlm.nih.gov/20974015/
Supplemented patients also displayed reductions in self-blame and higher problem-solving skills after the study. Even people who don’t consider themselves “high-stress” may attain a serenity boost from this novel probiotic combination. When the same research team analyzed data on 25 original study participants whose baseline cortisol was below the median, indicating generally lower stress, they found that these individuals also experienced marked improvements in mood scores.
Additionally, other research highlights that a month-long regimen of Lactobacillus helveticus and Bifidobacterium longum significantly improved neuropsychiatric states, including reductions in cortisol levels and improvements in mood disorders such as anger and anxiety (MentalHealthDaily) (NeuroPsych Journal). Another meta-analysis of randomized controlled trials supports these findings, showing that probiotics can reduce anxiety symptoms in various populations, including healthy individuals and those under stress (NeuroPsych Journal).
Overall, these studies suggest that specific probiotic strains, particularly Lactobacillus helveticus and Bifidobacterium longum, could be beneficial as a natural supplement for managing stress, anxiety, and depression.
Conclusion:
Combining ashwagandha with magnesium and probiotics with Bifidobacterium longum & Lactobacillus helveticus presents a compelling synergy that supports holistic wellness, from stress reduction and mood enhancement to improved sleep quality, muscle relaxation, cognitive function, and cardiovascular health. Whether you're looking to manage stress, enhance athletic performance, or simply support your overall health, integrating these powerful supplements into your daily routine could be a beneficial step towards achieving optimal well-being.
GREENDORSE’s Calm & Relax formulation stands out as a comprehensive solution for individuals seeking to manage stress, support mental clarity, and enhance physical well-being. Backed by rigorous scientific research and formulated with premium ingredients, this blend offers holistic support for a balanced and healthier lifestyle. Embrace the benefits of magnesium, potent Ashwagandha, and clinically studied probiotics to achieve optimal calm and relaxation in your daily life.
Why Choose GREENDORSE?
Quality and Potency: Our formula incorporates high-quality ingredients with clinically proven efficacy, ensuring you receive optimal benefits.
Research-Backed: Backed by 11 international research publications and 6 patents in Europe and the US, our Shoden Ashwagandha sets a new standard in efficacy and reliability.
Comprehensive Support: Whether you struggle with stress, sleep issues, muscle cramps, or simply want to enhance your overall well-being, our Calm & Relax Formula provides holistic support.
References: 1. Adrian L. Lopresti et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract; A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep; 98(37): e17186.
2. Behnood Abbasi et al. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012 Dec; 17(12): 1161–1169.
3. Ana Carolina Remondi Souza et al. The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review. Nutrients 2023, 15(24), 5127.
4. Alyssum M Reno. Effects of Magnesium Supplementation on Muscle Soreness and Performance. J Strength Cond Res
. 2022 Aug 1;36(8):2198-2203.
5. Michaël Messaoudi et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr
. 2011 Mar;105(5):755-64.
7. Ruixue Huang et al. Efficacy of Probiotics on Anxiety: A Meta-analysis of Randomized Controlled Trials. Research Article - Neuropsychiatry (2017) Volume 7, Issue 6.
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